Anna Łęczkowska

 

Contact

 

 
Room

Phone

Email

 Ha308

+ 44 121 4148068

axl640@bham.ac.uk

 

Status

 PhD Student

 

Date joined group

 January 2007

Qualifications

     SCIENTIFIC INTERESTS

 

       The design of new metallo-drugs that target DNA through non-covalent interactions. The study of helical Ru complexes          with different structural topologies, their corresponding DNA binding affinities and  anticancer activity.

 

 

 

      EDUCATION

 

       PhD

                              

 

Marie Curie Fellowship, University of Birmingham, School of Chemistry, Birmingham, UK Project: “Supramolecular DNA recognition” (01.2007- )

 

 

                            MSc  

 

Nicolaus Copernicus University, Department of Chemistry, Toruń, Poland

Master thesis: “Synthesis and study of cobalt (III) complexes with imidazole and its N-derivatives” (10.2001-06.2006)

 

 

      OTHER RESEARCH PROJECTS

          

    

       9-12.2006

 

 

Magnetic Resonance Center, CERM, University of Florence, Florence, Italy

Project: “Expression of proteins co-involved in apoptosis”

 

 

       9-12.2005    

National and Kapodistrian University of Athens, Department of Chemistry, Athens, Greece Socrates/Erasmus scholarship,

Project: “Synthesis and characterization of mono- and bi-metallic transition metal complexes”  

 

 

      MEETINGS AND CONFERENCES

 

  • Supra-Nano 2008, 16-18th December 2008, University of Birmingham, Birmingham, UK, “Supramolecular DNA binding of Ru(II) unsaturated helicates”, Anna Łęczkowska and Michael J. Hannon (p. P68 in the Book of Abstracts, Poster Presentation)

 

  • Annual UK/EU Circular Dichroism Meeting, 4th December 2008, Warwick University, Warwick, UK

 

  • INTCHEM Summer College, “Non-Covalent Interactions in Chemistry and Biochemistry”, 21-27th September 2008, Lesna, Poland, “Non-Covalent DNA  recognition by novel helical metallo-drugs”, Anna Łęczkowska and Michael J. Hannon (p. 19 in the Book of Abstracts, Oral Communication and Poster Presentation)

 

  • COST D31 “Organizing non-covalent chemical systems with selected functions”, WG D231/0008/04 Meeting: Functional Helicates. 28th March 2008, University of Geneva, Geneva, Switzerland. “Synthesis, DNA binding studies and biological activity of dinuclear ruthenium (II) triple-stranded helicate”, Anna Łęczkowska, Gabriel Pascu, Carlos Sanchez-Cano and Michael J. Hannon (Poster Presentation)

 

  • COST D39 “Metallo-Drug Design and Action” WG D39/0002/07 Meeting: ‘Metallo-drugs that act  through non-covalent interactions’. 15-16th  October 2007, University of Birmingham, Birmingham,  UK

PUBLICATIONS                                                                                                                                       

  • Ruthenium polypyridyl complexes and their modes of interaction with DNA: Is there a correlation between these interactions and the antitumor activity of the compounds, E. Corral, A.C. Hotze, H. den Dulk, A. Leczkowska, A. Rodger, M.J. Hannon and J. Reedijk, J Biol Inorg Chem. 2009. DOI 10.1007/s00775-008-0460-x  Available online Dec 16. 2008 

 

     MEMBERSHIPS

 

       Royal Society of Chemistry (RSC)

      Society of Chemical Industry (SCI)

 

 

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