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Peacock, A. F. A.; Iranzo, O.; Pecoraro, V. L. (2009) Harnessing natures ability to control metal ion coordination geometry using de novo designed peptides, Dalton Transactions, 13, 2271-2280. Cover. Van Rijt, S. H.; Peacock, A. F. A.; Johnstone, R. J. L.; Parsons, S.; Sadler, P. J. (2009) Organometallic osmium(II) arene anticancer complexes containing picolinate derivatives, Inorganic Chemistry, 48, 1753-1762. Peacock, A. F. A.; Hemmingsen, L.; Pecoraro, V. L. (2008) Using diastereopeptides to control metal ion coordination in proteins, Proceedings of the National Academy of Science, USA, 105, 16566-16571. Peacock, A. F. A.; Sadler, P. J. (2008) Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents, Chemistry an Asian Journal, 3, 1890-1899. VIP article. Kostrhunova, H.; Florian, J.; Novakova, O.; Peacock, A. F. A.; Sadler, P. J.; Brabec, V. (2008) DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media, Journal of Medicinal Chemistry, 51, 3635-3643. Peacock, A. F. A.; Habtemariam, A.; Moggach, S. A.; Prescimone, A.; Parsons, S.; Sadler, P. J. (2007) Chloro Half-Sandwich Osmium(II) Complexes: Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding and Cytotoxicity, Inorganic Chemistry, 46, 4049-4059. Peacock, A. F. A.; Parsons, S.; Sadler, P. J. (2007) Tuning the Hydrolytic Aqueous Chemistry of Osmium Arene Complexes with N,O-Chelating Ligands to Achieve Cancer Cell Cytotoxicity, Journal of the American Chemical Society, 129, 3348-3357. Peacock, A. F. A.; Melchart, M.; Deeth R. J.; Habtemariam, A.; Parsons, S.; Sadler, P. J. (2007) Osmium(II) and Ruthenium(II) Arene Maltolato Complexes: Rapid Hydrolysis and Nucleobase Binding, Chemistry a European Journal, 13, 2601-2613. Yan, Y. N.; Melchart, M.; Habtemariam, A.; Peacock, A. F. A.; Sadler, P. J. (2006) Catalysis of Regioselective Reduction of NAD+ by Ruthenium(II) Arene Complexes Under Biologically-Relevant Conditions, Journal of Biological Inorganic Chemistry, 11, 483-488. Peacock, A. F. A.; Habtemariam, A.; Fernández, R.; Walland, V.; Fabbiani, F. P. A.; Parsons, S.; Aird, R. E.; Jodrell, D. I.; Sadler, P. J. (2006) Tuning the Reactivity of Osmium(II) and Ruthenium(II) Arene Complexes under Physiological Conditions, Journal of the American Chemical Society, 128, 1739-1748 Peacock, A. F. A.; Batey, H. D.; Raendler, C.; Whitwood, A. C.; Perutz, R. N.; Duhme-Klair, A.-K. (2005) A Metal-Based Lumophore Tailored To Sense Biologically Relevant Oxometalates, Angewandte Chemie, International Edition, 44, 1712-1714. |
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The Peacock Group Website |
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Peacock, A. F. A.*, (2013) Incorporating metals into de novo proteins, Curr. Opin. Chem. Biol., 17 (6), 934-939, Invited contribution Special Edition. Eds D. N. Woolfson, S.-C. Hung. |
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Zastrow, M. L.; Peacock A.F.A.; Stuckey J. A.; Pecoraro V. L. (2012) Hydrolytic catalysis and structural stabilization in a designed metalloprotein, Nature Chem., 4, 118-123. |
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Chakraborty, S.; Touw, D. S.; Peacock, A. F. A.; Stuckey, J. A.; Pecoraro, V. L. (2010) Structural Comparisons of Apo- and Metalated Three Stranded Coiled Coils Clarify Metal Binding Determinants in Thiolate Containing Designed Peptides, Journal of the American Chemical Society, 132, 13240-13250. |
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Bergamo, A.; Masi, A.; Peacock, A. F. A.; Habtemariam, A.; Sadler, P. J.; Sava, G. (2010) In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model, Journal of Inorganic Biochemistry, 104, 79-86.
Peacock, A. F. A.; Stuckey, J. A.; Pecoraro, V. L. (2009) Switching the Chirality of the Metal Environment Alters the Coordination Mode in Designed Peptides, Angewandte Chemie International Edition, 48, 7371-7374. Inside Cover. |
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A. F. A. Peacock, V. L. Pecoraro, in "Cadmium: From Toxicity to Essentiality", Vol. 11 of 'Metal Ions in Life Sciences', A. Sigel, H. Sigel, R. K. O. Sigel, Eds.; Springer Science + Business Media B.V., Dordrecht, 2013, pp 303-337, ISBN 978-94-007-5179-8 |
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S. H. Van Rijt, A. F. A. Peacock, P. J. Sadler, Osmium arenes - a new class of potential anticancer agents. In: A. Bonetti, R. Leone, F. Muggia and S. B. Howell (eds.) Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications. Humana Press, 2009, pp 73-79, ISBN: 978-1-60327-458-6 |
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V. L. Pecoraro, A. F. A. Peacock, O. Iranzo, M. Łuczkowski; Chapter 12: Understanding the Biological Chemistry of Mercury Using a de novo Protein Design Strategy. In: E. Long, M. Baldwin (eds.) Advances in Inorganic Biochemistry: From Synthetic Models to Cellular Systems. ACS Symposium Series No. 1012, 2009, pp 183-197, ISBN: 978-0-8412-6975-0. |
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Patents
UK Patent Application Number 1403268.4, filed February 2014 UK Patent Application Number 1401453.4, filed January 2014 P. J. Sadler, A. F. A. Peacock, S. H. Van Rijt, A. Habtemariam, Preparation and antitumor activity of organometallic osmium compounds PCT Int. Appl. (2008), 91pp. CODEN: PIXXD2 WO 2008017855 A1 20080214 |
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Peacock, A. F. A.*; Bullen, G. A.; Gethings, L.; Williams, J. P.; Kriel, F. H.; Coates, J. (2012) Gold-Phosphine Binding to De Novo Designed Coiled Coil Peptides, J. Inorg. Biochem., 117, 298-305, Invited contribution Special Edition. Eds M. Capdevila, J. M. Dominguez-Vera, S. Atrian and Ò. Palacios. |
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Oheix, E.; Spencer, N.; Gethings, L. A.; Peacock, A. F. A.*(2013) Conformational study of an artificial metal-dependent regulation site for use in designer proteins, Z. Anorg. Allg. Chem., 639 (8-9), 1370-1383, Invited contribution Special Edition. Eds J. Reedijk, B. Krebs. |
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Oakley, M. T.; Oheix, E.; Peacock, A. F. A.; Johnston, R. L., (2013) Computational and Experimental Investigations into the Conformations of Cyclic Tetra-α/β-Peptides, J. Phys. Chem. B, 117 (27), 8122-8134. |
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Berwick, M. R.; Lewis, D. J.; Jones, A. W.; Parslow, R. A.; Dafforn, T. R.; Cooper, H. J.; Wilkie, J.; Pikramenou, Z.; Britton, M. M.; Peacock, A. F. A.* (2014), De Novo Design of Ln(III) Coiled Coils for Imaging Applications, J. Am. Chem. Soc., 136, 1166-1169. Featured in The Conversation |
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Oheix E., Peacock A. F. A.*, (2014), Metal ion regulated miniature DNA binding proteins based on GCN4 and non-native regulation sites, Chem. Eur. J., 20 (10), 2829-2839. |
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A. J. Gamble, A. F. A. Peacock "De Novo Design of Peptide Scaffolds as Novel Preorganized Ligands for Metal-Ion Coordination" in "Protein Design" (in the lab-protocol based 'Methods in Molecular Biology' series published by V. Köhler Ed.; Humana Press (part of the Springer publishing group), 2014, pp 211-232, ISBN 978-1-4939-1485-2 |
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E. Oheix, A. F. A. Peacock "De novo designed metallopeptides" in "Amino acids, peptides and proteins: Volume 39", 2015, pp 148-191. DOI:10.1039/9781849739962-00148 |
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Book Chapters |
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Papers Micah Kelly, Richard Williams, Anuriti Aojula, Jenna O'Neill, Zuzanna Trzińscka, Liam Grover, Robert A.H. Scott, Anna F.A. Peacock, Ann Logan, Artemis Stamboulis, Felicity de Cogan. (2015) Peptide Aptamers: Novel coating for orthopaedic implants, Materials Science and Engineering: C, 54, 84-93
Gemma A. Bullen, James H. R. Tucker and Anna F. A. Peacock. Exploiting anthracene photodimerization within peptides: light induced sequence-selective DNA binding Chemical Communications, 2015, 51, 8130 - 8133 |
