De novo peptide design, DNA binding metallopeptides, gadolinium coiled coils




Design of peptide architectures for DNA binding

Our group is interested in the design of peptide sequences which fold into well-defined structures capable of both selective DNA recognition and binding. This is achieved by utilising the α-helix as the DNA major groove recognition domain. We are interested in the design of metal sites which are able to preorganise the α-helices so as to enhance DNA binding, and which are capable of providing a measurable output with potential sensor applications.

Development of gadolinium coiled coil complexes


A second project within the group involves the design, synthesis and evaluation of gadolinium coiled coil complexes as potentially novel MRI contrast agents. By correlating peptide design, solution studies and computational modelling with MR data, we aim to understand the mechanism by which we produce contrast and develop a new class of gadolinium complexes with enhanced relaxivity.

The Peacock Group Website

Text Box: Research

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