Ariel Mucha

Contact

Phone

Email

+ 44 121 4148862

 a.mucha@bham.ac.uk

Status

In the group

Research interests

Novel Supramolecular cylinders and their interaction with DNA; probing effects of cylinder structure and targeting DNA junctions
 

Professional experiences  

29.01.2009: defence of the Ph.D. thesis with suma cum laude

2004-2008: Ph.D. studies in Bioinorganic and Biomedical Chemistry Research Group, Faculty of Chemistry, University of Wrocław, (Ph.D. thesis: Complexes of nickel(II) ions with adenine nucleotide. Influence of the metal ion on the damage of nucleic acids and their structural elements)

1999-2004: M.Sc. studies (Environmental Chemistry), Faculty of Chemistry, University of Wrocław

10/2009-03/2010: Post-Doctoral Research Fellow (Marie Curie Action Transfer of Knowledge programme on "Lipidomics in Human Development, Health and Chronic Diseases (LIPHEALTH)", Institute of Brain Chemistry and Human Nutrition (IBCHN) London Metropolitan University

2009: Assistant Professor (adjunct), Wrocław Research Center EIT+, Wrocław

08/2007-02/2008: Ph.D. Student Research Fellow in the group of Prof. Roland K.O. Sigel, Institute of Inorganic Chemistry, University of Zurich, Switzerland. Fellowship from the International Relations Office of the University of Zurich

1.  B. Knobloch, A. Mucha, B.P. Operschall, H. Sigel, M. Jeżowska-Bojczuk, H. Kozłowski, R.K.O. Sigel, Stability and Structure of Mixed-Ligand Metal Ion Complexes That Contain Ni²⁺, Cu²⁺, or Zn²⁺, and Histamine, as well as Adenosine 5′-Triphosphate (ATP⁴⁻) or Uridine 5′-Triphosphate (UTP⁴⁻): An Intricate Network of Equilibria, Chem. Eur. J., 2011, 17, 5393-5403.

2.  A. Mucha, B. Knobloch, M. Jeżowska-Bojczuk, H. Kozłowski, R.K.O. Sigel, Comparison of the acid-base properties of ribose and 2'-deoxyribose nucleotides, Chem. Eur. J., 2008, 14, 6663-6671.

3.  A. Mucha, B. Knobloch, M. Jeżowska-Bojczuk, H. Kozłowski, R.K.O. Sigel, Effect of the ribose versus 2'-deoxyribose residue on the metal ion-binding properties of purine nucleotides, Dalton Trans., 2008, 5368-5377.

4.  A. Mucha, W. Bal, M. Jeżowska-Bojczuk, Comparative studies of coordination properties of puromycin and puromycin aminonucleoside towards copper(II) ion, J. Inorg. Biochem., 2008, 102, 46-52.

5.  M. Cappanelli, E. Gaggelli, M. Jeżowska-Bojczuk, E. Molteni, A. Mucha, E. Porciatti, D. Valensin, G. Valensin, ¹H- and ¹³C-NMR study of the complex formed by copper (II) with the nucleoside antibiotic - sinefungin, J. Inorg. Biochem., 2007, 101, 1005-1012.

6.  M. Jaworska, P. Lodowski, A. Mucha, W. Szczepanik, M. Cappanelli, G. Valensin, M. Jeżowska-Bojczuk, Characterization of copper(II) interactions with sinefungin, a nucleoside antibiotic. Combined potentiometric, spectroscopic and DFT studies, Bioinorg. Chem. Applications, 2007, doi:10.1155/2007/53521.

7.  A. Mucha, M. Cappanelli, W. Szczepanik, P. Kaczmarek, J. Skała, M. Jeżowska-Bojczuk, Influence of the physiologically widespread substances on the oxidative activity of copper(II) complexes with sinefungin, a nucleoside antibiotic, J. Inorg. Biochem., 2006, 100, 178-185.